A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/285 (2006.01) A61P 31/20 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2725383
The present invention relates to DNA vaccines that are capable of generating a protective immune response in mammals against a pox virus, and comprises at least one DNA plasmid capable of expressing a plurality of VACV MV antigens, and at least one DNA plasmid capable of expressing a plurality of VACV EV antigens. Also, the present invention relates to methods of inducing a protective immune response in a mammal to pox virus, including a neutralizing antibody response, com-prising: injecting into tissue of said mammal said DNA vaccine.
La présente invention concerne des vaccins à ADN capables de susciter une réponse immunitaire protectrice contre un poxvirus chez les mammifères. Ils contiennent au moins un ADN plasmidique capable d'exprimer une pluralité d'antigènes MV du VACV et au moins un ADN plasmidique capable d'exprimer une pluralité d'antigènes EV du VACV. La présente invention concerne également des procédés permettant de susciter une réponse immunitaire protectrice contre un poxvirus chez un mammifère, y compris sous la forme de la production d'anticorps neutralisants, procédés comprenant l'injection dans un tissu dudit mammifère dudit vaccin à ADN.
Draghia-Akli Ruxandra
Hirao Lauren A.
Prigge John
Sardesai Niranjan Y.
Weiner David B.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Trustees Of The University Of Pennsylvania
Vgx Pharmaceuticals Inc.
Vgx Pharmaceuticals Llc
LandOfFree
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