Smooth muscle cell proliferation inhibitors

Details Smooth muscle cell proliferation inhibitors Smooth muscle cell proliferation inhibitors

C - Chemistry, Metallurgy

07

H

C07H 15/18 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2204529

This invention comprises polyanionic benzylglycosides of benzene triacid amides of general formula (I) wherein each of R1, R2, R3 and R4 are, independently, H, SO3M, or (a) and each oligosaccharide group contains 1 to 3 sugar groups; M is lithium, sodium, potassium, or ammonium; n is 1 or 2; X is a halogen, lower alkyl having 1 to 6 carbon atoms, or lower alkoxy having 1 to 6 carbon atoms; Y is carbonyl or sulfonyl; or the pharmaceutically acceptable salts thereof, as well as their use as smooth muscle cell antiproliferation inhibitors and as therapeutic compositions for treating diseases and conditions which are characterized by excessive smooth muscle proliferation.

L'invention a pour objet des benzylglycosides polyanioniques d'amides de triacide de benzène de la formule (I) dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ représentent indépendamment H, SO¿3?M, ou (a). Chaque groupe d'oligosaccharides contient 1 à 3 groupes de sucre; M représente du lithium, du sodium, du potassium ou de l'ammonium; n est égal à 1 ou 2; X représente un halogène, un alkyle inférieur comportant 1 à 6 atomes de carbone, ou de l'alcoxy inférieur comportant 1 à 6 atomes de carbone; Y représente du carbonyle ou du sulfonyle; ou les sels pharmaceutiquement acceptables de ces derniers. L'invention traite également de l'utilisation de ces produits comme inhibiteurs de l'antiprolifération des cellules des muscles lisses et dans des compositions thérapeutiques pour traiter les maladies et les états qui sont caractérisées par une prolifération excessive de muscles lisses.

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