Smooth muscle spasmolytic agents

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 211/01 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2522888

The present invention relates to smooth muscle spasmolytic agents, pharmaceutical compositions containing them and method of using said compounds and compositions for the treatment of urinary incontinence, and other smooth muscle contractility conditions. More particularly, the present invention relates to certain metabolically stabilized secondary amines having smooth muscle relaxing properties while avoiding, on administration to a mammal, adverse side effects such as prominent antimuscarinic, arrhythmogenic and cardiodepressive effects.

La présente invention concerne des agents spasmolytiques pour muscles lisses, des compositions pharmaceutiques les contenant ainsi qu'une méthode d'utilisation de ces composés et compositions pour le traitement de l'incontinence urinaire et autres états de contractilité des muscles lisses. Cette invention concerne plus particulièrement certaines amines secondaires métaboliquement stabilisées qui présentent des effets relaxants sur les muscles lisses tout en étant dépourvues, lorsqu'elles sont administrées à des mammifères, d'effets secondaires indésirables tels que les effets antimuscariniques, arythmogéniques et cardiodépresseurs.

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