A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/23 (2006.01) A61K 31/20 (2006.01) A61K 31/201 (2006.01) A61P 3/04 (2006.01)
Patent
CA 2736746
A nutritional fat or oil-based composition for increasing HDL cholesterol, decreasing LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma is described. The composition can advantageously include at least 1% by weight myristic acid esterified at the sn-2 position in triglyceride molecules, includes between 10% and 40% by weight linoleic acid, and further includes between 30% and 65% by weight oleic acid and between 15% and 40% by weight total saturated fatty acids. The ratio of sn-2 myristic acid to sn-2 palmitic acid is typically greater than 1:1 and the sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free.
L'invention concerne une composition à base d'huile ou de graisse nutritionnelle, destinée à augmenter le cholestérol HDL, réduire le cholestérol LDL et réduire le rapport cholestérol LDL/HDL dans le plasma humain. Cette composition peut contenir avantageusement : au moins 1 % en poids d'acide myristique estérifié au niveau de la position sn-2 dans les molécules de triglycérides ; entre 10% et 40% en poids d'acide linéique ; et entre 30% et 65% en poids d'acide oléique et entre 15% et 40% en poids d'acides gras saturés totaux. Le rapport acide myristique sn-2 /acide palmitique sn-2 est généralement supérieur à 1:1 et la somme des pourcentages en poids des acides gras saturés, mono-insaturés et poly-insaturés est égale à 100%. La composition selon l'invention est, de préférence, sensiblement exempte de cholestérol.
Hayes Kenneth C.
Perlman Daniel
Brandeis University
Smart & Biggar
LandOfFree
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