C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2383943
The transcription factor Snail has been identified as a repressor of the expression of cadherine E. The expression of Snail induces invasive and metastasic capacity in tumoral cells. The present invention discloses a new target protein, Snail, for the identification of new antitumoral compounds and it also discloses a new prognostic marker for tumors, indicative of tissue invasion and metastatic capacity.
On a identifié le facteur de transcription Snail comme répresseur de l'expression de la cadhérine E. L'expression de Snail induit la capacité invasive et métastatique dans les cellules tumorales. L'invention concerne une nouvelle protéine diana, le facteur Snail, permettant l'identification de nouveaux composés antitumoraux et un nouveau marqueur de pronostic de tumeurs indiquant l'invasion tissulaire et la capacité métastatique.
Blanco Fernandez de Valderrama Maria Jose
Cano Garcia Amparo
Garcia Del Barrio Marta
Locascio Annamaria
Nieto Toledano Maria Angela
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Consejo Superior de Investigaciones Cientificas
Universidad Autonoma de Madrid
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