C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2264544
The present invention provides novel human small nuclear ribonucleoprotein (snRNP) Sm proteins (collectively called HSMP) and polynucleotides which identify and encode HSMP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSMP. The invention also provides pharmaceutical compositions containing HSMP or antagonists to HSMP, and in the use of these compositions for the treatment of diseases associated with the expression of HSMP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSMP for the treatment of diseases associated with the expression of HSMP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding HSMP or anti-HSMP antibodies which specifically bind to HSMP.
La présente invention concerne de nouvelles protéines humaines Sm (appelées collectivement HSMP) de ribonucléoprotéines nucléaires de petite taille (snRNP), et des polynucléotides qui identifient et codent ces HSMP. Cette invention prévoit également des vecteurs d'expression mis au point génétiquement, et des cellules hôtes comprenant des séquences d'acides nucléiques codant des HSMP. Cette invention prévoit également des compositions pharmaceutiques contenant des HSMP ou des antagonistes de HSMP. De plus, cette invention prévoit l'utilisation de molécules antisens de polynucléotides codant des HSMP dans le traitement de maladies associées à l'expression de HSMP. Cette invention prévoit également des méthodes diagnostiques qui utilisent le polynucléotide, ou des fragments du complément de celui-ci, en vue d'une hybridation à la séquence génomique ou à des produits de transcription de polynucléotides codant des HSMP ou des anticorps anti-HSMP se liant spécifiquement à des HSMP.
Bandman Olga
Hillman Jennifer L.
Zweiger Gary B.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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