Sodium cefamandole crystalline forms

Details Sodium cefamandole crystalline forms Sodium cefamandole crystalline forms

C - Chemistry, Metallurgy

07

D

260/105

C07D 501/36 (2006.01)

Patent

CA 1089447

ABSTRACT OF THE DISCLOSURE A novel crystalline monohydrate of sodium 7-(D-2-hydroxy- 2-phenylacetamido)-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3- cephem-4-carboxylate is described herein. The novel mono- hydrate is prepared by either (a) exposing the crystalline methanol solvate of sodium 7-(D-2-hydroxy-2-phenylacetamido)-3-(1-methyl-1H- tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylate to water at a relative humidity of between about 40 and 60 percent and at a temperature between about 20° and 30°C; or (b) exposing the crystalline anhydrate of sodium 7-(D-2-hydroxy-2-phenylacetamido)-3-(1-methyl-1H-tetrazole- 5-ylthiomethyl)-3-cephem-4-carboxylate to water at a relative humidity of about 55 percent and at a temperature of about 25°C. It is an intermediate for preparing the crystalline anhydrate form of sodium cefamandole, which is an antibiotic.

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