Soft anticholinergic esters

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/10 (2006.01) A61K 31/40 (2006.01) A61K 31/439 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/10 (2006.01) A61P 27/08 (2006.01) C07D 451/10 (2006.01)

Patent

CA 2627982

Soft anticholinergic esters of the formulas (Ia) or (Ib): wherein R1 and R2 are both phenyl or one of R1 and R2 is phenyl and the other is cyclopentyl; R is C1-C8 alkyl, straight or branched chain; and X" is an anion with a single negative charge; and wherein each asterisk marks a chiral center; said compound having the R, S or RS stereoisomeric configuration at each chiral center unless specified otherwise, or being a mixture thereof.

L'invention concerne des esters anticholinergiques modérés représentés par les formules (Ia) ou (Ib), dans lesquelles R1 et R2 représentent un phényle, ou soit R1, soit R2 représente un phényle et l'autre représente un cyclopentyle; R représente alkyle en C1-C8, une chaîne linéaire ou ramifiée; X" représente un anion comportant une seule charge négative; et chaque astérisque indique un centre chiral. Ledit composé présente la configuration stéréoisomère R, S ou RS à chaque centre chiral, sauf indication contraire, ou un mélange de celles-ci.

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