Soft tissue and bone augmentation and bulking utilizing...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/34 (2006.01) C12N 5/077 (2010.01) A61P 43/00 (2006.01)

Patent

CA 2406393

The present invention provides muscle-derived progenitor cells that show long- term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.

L'invention concerne des cellules souches dérivées de muscles, possédant une longue survie après transplantation dans des tissus corporels, et pouvant augmenter les tissus mous après qu'elles aient été introduites (par exemple par injection, transplantation ou implantation) dans un site de tissu mou. L'invention concerne également des procédés d'isolation de celles souches dérivées de muscles, ainsi que des procédés de modification génétique de ces cellules, aux fins de thérapie par transfert de gènes. L'invention concerne encore des procédés d'utilisation de compositions comprenant des cellules souches dérivées de muscles et destinées à augmenter et étoffer des tissus mous mammifères, et notamment humains, dans le traitement de diverses états fonctionnels et esthétiques, notamment les malformations, blessures, faiblesses, maladies ou dysfonctionnements. L'invention porte tout particulièrement sur des traitements et améliorations de problèmes dermatologiques, de reflux gastro-oesophagien, de reflux vésico-urétéral, d'incontinence urinaire et anale, d'insuffisance cardiaque et d'infarctus du myocarde.

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