C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01)
Patent
CA 2709971
The present invention relates to a synthetic process for manufacturing Dutasteride comprising the mixed anhydride formation, subsequent reaction with 2,5- bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water. The invention also relates to a novel polymorphic form of Dutasteride, called form III, and a pharmaceutical composition comprising it.
L'invention concerne un procédé de synthèse pour la fabrication de dutastéride comprenant la formation d'anhydride mixte, la réaction ultérieure avec de la 2,5-bis(trifluorométhyl)phénylamine en présence d'un catalyseur de Lewis approprié et son isolation, sa purification et sa cristallisation à partir d'acétonitrile/d'eau. L'invention concerne également une nouvelle forme polymorphe de dutastéride, appelée forme III, et une composition pharmaceutique comprenant celle-ci.
Garcia Maria Beatriz
Labriola Rafael Alberto
Magnone Costanza Pia
Tombari Dora Graciela
Vecchioli Adriana
Gador S.a.
Garcia Maria Beatriz
Labriola Rafael Alberto
Magnone Costanza Pia
Shapiro Cohen
LandOfFree
Solid and crystalline dutasteride and processes for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Solid and crystalline dutasteride and processes for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid and crystalline dutasteride and processes for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1985974