A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4985 (2006.01) A61K 9/08 (2006.01) A61K 47/10 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2654902
This invention relates to oral pharmaceutical compositions suitable for making pharmaceutical formulations for oral administration that provide for the rapid dissolution of the phosphodiesterase 5 inhibitor tadalafil. In particular, the pharmaceutical compositions comprise solid composites of tadalafil exhibiting high solubility and rate of dissolution. The invention further relates to methods of preparing these pharmaceutical formulations and the use of such pharmaceutical formulations for treating diseases associated with PDE5 inhibitors.
L'invention concerne des compositions pharmaceutiques orales convenant à la préparation de formulations pharmaceutiques pour administration orale permettant la dissolution rapide de l'inhibiteur de phosphodiestérase 5, le tadalafil. Les compositions pharmaceutiques comprennent notamment des composites solides de tadalafil présentant une grande solubilité et une vitesse de dissolution élevée. L'invention concerne également des procédés de préparation de ces formulations pharmaceutiques et l'utilisation de telles formulations pharmaceutiques pour le traitement de maladies associées aux inhibiteurs de PDE5.
Pal Boaz
Zalit Ilan
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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