Solid dispersion comprising tacrolimus and enteric-coated...

Details Solid dispersion comprising tacrolimus and enteric-coated... Solid dispersion comprising tacrolimus and enteric-coated...

A - Human Necessities

61

K

A61K 9/00 (2006.01)

Patent

CA 2593825

This invention relates to a solid dispersion formulation comprising tacrolimus and enteric polymer. The solid dispersion formulation may contribute to better stability of tacrolimus preparation under high temperature and humidity condition through reduced recrystallization rate of tacrolimus. In addition, the solid dispersion formulation releases tacrolimus immediately in aqueous media and elevated solubility level maintains for certain period of time and that way the formulation may also enhance the bioavailability and oral absorption rate of tacrolimus.

La présente invention a trait à une formulation de dispersion de solides comportant du tacrolimus et un polymère entérique. La formulation de dispersion de solides peut contribuer à une meilleure stabilité de préparation de tacrolimus à condition de température et d'humidité élevées grâce au taux réduit de recristallisation du tacrolimus. En outre, la formulation de dispersion de solides assure la libération immédiate du tacrolimus en milieu aqueux et maintient un niveau de solubilité élevé pour une certaine période de temps et permet ainsi d'améliorer la biodisponibilité de la formulation et le taux d'absorption orale de tacrolimus.

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