Solid dispersion of a neurokinin antagonist

Details Solid dispersion of a neurokinin antagonist Solid dispersion of a neurokinin antagonist

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/4468 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2672402

Solid dispersion comprising (4R)-4-[N'-methyl-N'-(3,5-bistrifluoromethyl-benzoyl)-amino]-4-(3,4-dichlorobenzyl)-but-2-enoic acid N-[(R)-epsilon-caprolactam-3-yl]-amide or a pharmaceutically acceptable salt or solvate thereof and a carrier. Pharmaceutical compositions comprising such solid dispersion are useful to treat patients who have functional motility disorders of the viscera, especially irritable bowel syndrome or functional dyspepsia, or urinary bladder disorders, especially urinary incontinence.

L'invention concerne une dispersion solide comprenant le N-[(R)-epsilon-caprolactam-3-yl]-amide de l'acide (4R)-4-[N'-méthyl-N'-(3,5-bistrifluorométhyl-benzoyl)-amino]-4-(3,4-dichlorobenzyl)-but-2-énoïque ou un de ses sels pharmaceutiquement acceptables ou un de ses solvates et un véhicule. Des compositions pharmaceutiques comprenant une telle dispersion solide sont utiles pour traiter les patients souffrant de troubles fonctionnels de motilité des viscères, notamment le syndrome du côlon irritable ou la dyspepsie fonctionnelle, ou des troubles urinaires de la vessie, notamment l'incontinence urinaire.

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