Solid dispersions comprising a hygroscopic and/or...

Details Solid dispersions comprising a hygroscopic and/or... Solid dispersions comprising a hygroscopic and/or...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/14 (2006.01) A61K 31/155 (2006.01)

Patent

CA 2509261

A pharmaceutical composition is provided, comprising a solid dispersion having a carrier medium that comprises (a) a matrix forming agent selected from hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose phthalate, polyvinyl pyrrolidone, polyethylene glycol, polyglycolized glycerides, cyclodextrins and carbomers, and (b) a filler, and having a hygroscopic and/or deliquescent drug dispersed or dissolved in the carrier medium. The composition is acceptably non-hygroscopic.

L'invention concerne une composition pharmaceutique qui comprend une dispersion solide contenant un milieu de support. Ce dernier comprend : (a) un agent formateur de matrice sélectionné dans le groupe constitué d'hydroxyéthylcellulose, hydroxypropylcellulose, hydroxypropylméthylcellulose, hydroxypropylméthylcellulose phtalate, polyvinyl pyrrolidone, polyéthylène glycol, glycérides polyglycolisés, cyclodextrines et carbopols et (b) une charge ; et comprend également un médicament hygroscopique et/ou déliquescent dispersé ou dissout dans le milieu de support. Ladite composition présente un caractère non hygroscopique acceptable.

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