A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/164
A61K 9/66 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01)
Patent
CA 2020802
4-17661/= Solid dosage form for pharmaceutically active drugs Abstract of the Disclosure The invention relates to a solid pharmaceutical dosage form from which the active drug or mixture of drugs is able to go quantitatively into solution under controlled conditions, immediately or continuously and substantially independently of the pH, i.e. of the concentration of hydrogen ions and hydroxyl ions and/or of other ions and also of enzymes of the ambient fluid, after a specific time, i.e. after expiry of a specific interval of time, characterised in that said dosage form, which contains an active drug or a mixture of drugs, a non-colloidal, water-swellable excipient (disintegrator) and at least one water-soluble excipient (osmosis-inducing compound), together with optional adjuncts, is coated with a semi-permeable membrane which, after passage through it of water of the ambient body fluid, opens like an eyelid (ruptures) after a specific predetermined time as a consequence of the pressure exerted by the swellable non-colloidal excipient and by the simultaneously induced osmotic pressure and by any gas pressure created internally, and releases the active drug or mixture of drugs quantitatively. The invention further relates to the preparation and use of the solid pharmaceutical dosage form.
Ag Ciba-Geigy
Fetherstonhaugh & Co.
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