Solid dosage form of wetted heparin

Details Solid dosage form of wetted heparin Solid dosage form of wetted heparin

A - Human Necessities

61

K

A61K 31/727 (2006.01)

Patent

CA 2564866

The present invention relates to a solid pharmaceutical composition (such as a solid dosage form) comprising a delivery agent and wetted heparin. The inclusion of wetted heparin rather than un-wetted heparin in the solid pharmaceutical composition results in increased delivery of the heparin. Without being bound by any particular theory, applicants believe that because the polymer chain of the wetted heparin is already in an "open" form, while un- wetted heparin is not, less of the wetted heparin is broken down in the gastrointestinal tract and is more readily absorbed in the stomach.

L'invention concerne une composition pharmaceutique solide (telle qu'une forme de dosage solide) comprenant un agent d'administration et de l'héparine mouillée. L'inclusion d'héparine mouillée provoque, dans la composition pharmaceutique solide, beaucoup plus qu'une héparine non mouillée, une administration accrue de l'héparine. Sans aucun lien avec une théorie particulaire, les inventeurs estiment que du fait que la chaîne polymère d'héparine mouillée est déjà une forme <= ouverte >=, alors que l'héparine non mouillée ne l'est pas, moins d'héparine mouillée est décomposée dans le tractus gastro-intestinal et est plus facilement absorbée dans l'estomac.

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