Solid dosage forms of divalproex sodium

Details Solid dosage forms of divalproex sodium Solid dosage forms of divalproex sodium

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2431375

The present invention is directed to an aqueous process for granulating valproate compounds, in which the pH of the granulation solution is maintained at a pH of 5 or below. The invention is also directed to dosage forms in which the residual content of organic solvents is reduced to a level of 0.2w/w% or less.

La présente invention concerne un procédé de granulation aqueuse de composés valproate, dans lequel le pH de la solution de granulation est maintenu à une valeur inférieure ou égale à 5. Cette invention concerne également des formes posologiques dans lesquelles la teneur en résidus de solvants organiques est réduite à un niveau égal ou inférieur à 0,2 % en poids.

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