Solid dosage formulations of telcagepant potassium

Details Solid dosage formulations of telcagepant potassium Solid dosage formulations of telcagepant potassium

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2728547

A solid dosage pharmaceutical formulation comprising as an active ingredient the potassium salt of N-[(3R,6S)-6-(2,3-difluorophenyl)-2- oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl] -4-(2-oxo-2,3 -dihydro-1 H- midazo[4,5-b]pyridin-1-yl)piperidine-l-carboxamide (telcagepant), arginine, and a pharmaceutically acceptable surfactant. The invention is also directed to an amorphous form of the potassium salt of telcagepant.

L'invention porte sur une forme pharmaceutique posologique solide comprenant, comme principe actif, le sel de potassium du N-[(3R,6S)-6-(2,3-difluorophényl)-2-oxo-1-(2,2,2-trifluoroéthyl)azépan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)pipéridine-1-carboxamide (telcagepant), de l'arginine, et un agent tensio-actif pharmaceutiquement acceptable. L'invention porte également sur une forme amorphe du sel de potassium de telcagepant.

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