Solid forms of linezolid and processes for preparation thereof

Details Solid forms of linezolid and processes for preparation thereof Solid forms of linezolid and processes for preparation thereof

C - Chemistry, Metallurgy

07

D

C07D 263/20 (2006.01) A61K 31/421 (2006.01)

Patent

CA 2572207

Novel crystalline forms of Linezolid, designated as Form TIII, Form V, Form VI, Form IX, Form X, Form XII, Form XIV, Form XVII, and Form XVIII, are disclosed. The novel crystalline forms are characterized by powder X-ray diffraction, FTIR and FTRaman spectroscopy, and differential scanning calorimetry. Methods of preparing the novel crystalline forms, pharmaceutical compositions comprising the novel crystalline forms, and methods of using the novel crystalline forms to treat gram positive bacterial infections are also described. Amorphous Linezolid is also disclosed.

L'invention concerne de nouvelles formes cristallines du linézolide, connues sous les désignations de forme TIII, forme V, forme VI, forme IX, forme X, forme XII, forme XIV, forme XVII et forme XVIII. Les nouvelles formes cristallines sont caractérisées par une diffraction des rayons X sur poudre, la spectroscopie FTIR et FTRaman, et la calorimétrie à balayage différentiel. L'invention concerne en outre des procédés de préparation des nouvelles formes cristallines, des compositions pharmaceutiques comprenant lesdites nouvelles formes cristallines, ainsi que des procédés d'utilisation de ces nouvelles formes cristallines pour le traitement d'infections bactériennes Gram positif. L'invention concerne également un linézolide amorphe.

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