Solid forms of salts with tyrosine kinase activity

Details Solid forms of salts with tyrosine kinase activity Solid forms of salts with tyrosine kinase activity

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/496 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2480325

The present invention relates to solid forms of the hydrochloridesalt3-[5-(4- methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

La présente invention concerne des formes solides de sel hydrochlorure 3-[5-(4-méthanesulfonyl-piperazin-1-ylméthyl)-1H-indol-2-yl]-1H-quinolin-2-one qui inhibent, régulent et/ou modulent la transduction du signal de tyrosine kinase, des compositions qui contiennent ces composés et des techniques d'utilisation de celles-ci pour traiter des maladies et des pathologies dépendantes de la tyrosine kinase, telles que l'angiogenèse, le cancer, la croissance tumorale, l'athérosclérose, la dégénération maculaire liée à l'âge, la rétinopathie diabétique, des maladies inflammatoires et d'autres pathologies de cet ordre rencontrées chez des mammifères.

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