Solid forms of tenofovir disoproxil

C - Chemistry – Metallurgy – 07 – F

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Details

C07F 9/6561 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2709219

The present invention provides Tenofovir disoproxil succinate, Tenofovir disoproxil L-tartrate, Tenofovir disoproxil oxalate, Tenofovir disoproxil saccharate, Tenofovir disoproxil citrate, Tenofovir disoproxil salicylate and various solid forms thereof, methods for the preparation thereof and their use in pharmaceutical applications, in particular in anti-HIV medicaments. The forms of Tenofovir disoproxil can be used in combination with other anti-HIV medicaments such as Efavirenz and Emtricitabine.

La présente invention concerne du succinate de ténofovir disoproxil, du L-tartrate de ténofovir disoproxil, d'oxalate de ténofovir disoproxil, de saccharate de ténofovir disoproxil, du citrate de ténofovir disoproxil, du salicylate de ténofovir disoproxil et diverses formes solides de ceux-ci, des procédés pour leur préparation et leur utilisation dans des applications pharmaceutiques, notamment dans des médicaments anti-VIH. Les formes de ténofovir disoproxil peuvent être utilisées en combinaison avec d'autres médicaments anti-VIH tels que l'éfavirenz et l'emtricitabine.

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