C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 7/22 (2006.01) A61K 31/32 (2006.01) A61K 31/409 (2006.01) A61K 33/24 (2006.01) C07D 487/22 (2006.01)
Patent
CA 2417783
Solid forms of tin ethyl etiopurpurin (SnET2), including crystalline form I, crystalline Form II, disordered Form II, and an amorphous form are disclosed. Also disclosed are the 1,2-dichloroethane solvate of SnET2 and the N,N- dimethylformamide solvate of SnET2. These solid forms of SnET2 are useful as pharmaceuticals that exhibit pharmacological activity when irradiated with light and thus are useful in photodynamic therapy. Also disclosed are methods for making these solid forms of SnET2 and pharmaceuticals including these solid forms of SnET2.
L'invention concerne des formes solides d'éthyl étiopurpurine d'étain (SnET2), comprenant une forme cristalline I, une forme cristalline II, une forme II désordonnée, et une forme amorphe. L'invention concerne également le solvate 1,2-dichloroéthane de SnET2 et le solvate N,N-diméthylformamide de SnET2. Ces formes solides de SnET2 sont utilisées comme produits pharmaceutiques présentant une activité pharmacologique lorsqu'ils sont irradiés de lumière et sont, par conséquent, utiles dans la thérapie photodynamique. L'invention concerne également des méthodes de fabrication de ces formes solides de SnET2 et des produits pharmaceutiques comprenant ces formes solides de SnET2.
Garcia Barbara A.
Robinson Byron C.
Stahly G. Patrick
Miravant Pharmaceuticals Inc.
Smart & Biggar
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