Solid formulation

A - Human Necessities – 61 – K

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Details

A61K 31/522 (2006.01) A61K 9/20 (2006.01) A61K 47/38 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2532093

A solid pharmaceutical preparation which comprises crystalline cellulose and either a xanthine derivative represented by the formula (I): (I) (II) (wherein R1, R2, and R3 are the same or different and each represents hydrogen, lower alkyl, lower alkenyl, or lower alkynyl and R4 represents cycloalkyl, -(CH2)n- R5, or the formula (II) shown above) or a pharmacologically acceptable salt of the derivative. The preparation is excellent in properties (e.g., hardness, disintegrability, releasability, and stability).

L'invention concerne une préparation pharmaceutique solide comprenant une cellulose cristalline et soit un dérivé de xanthine représenté par la formule (I) ou (II) soit un sel de ce dérivé pharmaceutiquement acceptable. Dans la formule (I) R?1¿, R?2¿ et R?3¿ sont identiques ou différents, et chacun représente hydrogène, alkyle inférieur, alcényle inférieur, et R?4¿ représente cycloalkyle, -(CH¿2?)¿n?-R?5¿. Ladite préparation possède d'excellentes propriétés (par exemple, dureté, désintégration, libération et stabilité).

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