Solid orally ingestible formulations of tetrodotoxin

A - Human Necessities – 61 – K

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Details

A61K 31/529 (2006.01) A61K 9/28 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2570709

The present invention refers to an outwardly solid or completely solid ( or designed to be orally ingested)composition of tetrodotoxin and/or analogs or derivatives thereof. The tetrodotoxin present in this composition can be in the form of a racemate, as a mixture of stereoisomers or as a pure stereoisomer. The composition can be in the form of a tablet, a capsule, a drop or a dragee. It can comprise a gastroenteric coating and be formulated as an immediate release formulation or as a controlled release formulation. The tetrodotoxin composition is used for the treatment of pain.

La présente invention concerne une composition extérieurement solide ou entièrement solide (ou conçue pour être administrée par voie orale) de tétrodotoxine et/ou de produits analogues ou de leurs dérivés. La tétrodotoxine présente dans cette composition peut être sous forme racémique en tant que mélange de stéréoisomères ou en tant que stéréoisomère pur. La composition peut être sous forme de tablette, de capsule, de goutte ou de dragée. Elle peut comprendre un enrobage gastroentérique et peut être formulée comme une formulation à libération immédiate ou comme une formulation à libération contrôlée. La composition de tétrodotoxine est utilisée pour le traitement de la douleur.

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