Solid pharmaceutical composition comprising amlodipine and...

A - Human Necessities – 61 – K

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Details

A61K 31/44 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2749957

The present invention relates to a solid pharmaceutical composition for preventing or treating cardio-vascular disorders comprising amlodipine and losartan as active ingredients, and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium, and crosspovidone, which exhibits a high and stable level of amlodipine and losartan dissolution rates.

La présente invention concerne une composition pharmaceutique solide destinée au traitement prophylactique ou thérapeutique de maladies cardio-vasculaires et comprenant de l'amlodipine et du losartan au titre de principes actifs, ainsi qu'un agent délitant qui est un mélange d'au moins deux composants choisis dans le groupe constitué par le glycolate d'amidon sodium, le croscarmellose sodium et la crospovidone, ladite composition présentant des vitesses de dissolution de l'amlodipine et du losartan élevées et stables.

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