A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/427 (2006.01) A61K 9/10 (2006.01) A61K 9/28 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2669938
The present invention features solid pharmaceutical dosage formulations comprising ritonavir. As a non-limiting example, a dosage form of the present invention comprises a solid dispersion or solid solution of ritonavir in a matrix, where the matrix comprises at least one water-soluble polymer, such as copovidone, and at least one surfactant, such as polyoxyl 40 hydrogenated castor oil or macrogolglycerol hydroxystearate. Preferably, the solid dispersion or solution does not include, or includes only an insignificant amount of, PEG.
L'invention concerne des formulations de dosage pharmaceutique solides comprenant du ritonavir. Dans un exemple non limitatif, une forme de dosage de l'invention comprend une dispersion solide ou une solution solide de ritonavir dans une matrice, ladite matrice comprenant au moins un polymère soluble dans l'eau, tel que la copovidone, et au moins un tensioactif, tel que de l'huile de ricin hydrogénée polyoxyl 40 ou un macrogolglycérol-hydroxystéarate. De préférence, la dispersion ou la solution solide ne comprend pas de polyéthylène glycol (PEG) ou comprend uniquement une quantité insignifiante de PEG.
Alani Laman
Berndl Gunther
Breitenbach Joerg
Cai Yan
Fastnacht Katja
Abbott Laboratories
Torys Llp
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