A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2676684
The present invention relates to solid pharmaceutical formulations of a homogeneous dispersion of at least one active principle which possesses pH- dependent solubility, e.g. 1-[4-chloroanilino]-4-[4-pyridylmethyl]phthalazine, or a pharmaceutically acceptable salt thereof, to solid dosage forms comprising said solid pharmaceutical formulations, to methods of preparing said solid pharmaceutical formulations and said solid dosage forms, to uses of said solid pharmaceutical formulations, alone or in combination with one or more pharmaceutically active compounds, for the manufacture of a medicament for the treatment especially of a proliferative disease, such as cancer, and to a method of treatment of a proliferative disease, such as cancer.
L'invention se rapporte à des formulations pharmaceutiques solides d'une dispersion homogène d'au moins un principe actif possédant une solubilité dépendante du pH, p.ex. une 1 -[4-chloroanilino]-4-[4-pyridylméthyl]phthalazine, ou d'un sel pharmaceutiquement acceptable de ce dernier, à des formes posologiques solides renfermant lesdites formulations pharmaceutiques, à des procédés de préparation des formulations pharmaceutiques solides et des formes posologiques solides précitées, à des utilisations desdites formulations pharmaceutiques, seules ou combinées à un ou plusieurs composés pharmaceutiquement actifs, dans la fabrication d'un médicament destiné en particulier au traitement d'une maladie proliférative telle que le cancer, et à un procédé de traitement d'une maladie proliférative telle que le cancer.
Gysler Jens
Juergens Kai
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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