Solid pharmaceutical preparation containing 9-deoxo-...

Details Solid pharmaceutical preparation containing 9-deoxo-... Solid pharmaceutical preparation containing 9-deoxo-...

A - Human Necessities

61

K

167/123, 167/185

A61K 47/00 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/30 (2006.01) A61K 9/50 (2006.01)

Patent

CA 1271138

Abstract Solid pharmaceutical preparation The invention relates to a solid pharmaceutical preparation for oral administration, comprising as active substance a mixture of 9-deoxo-11-deoxy- 9,11-[imino[2-(2-methoxyethoxy)ethylidene]-oxy]- (9S)-erythromycin intimately mixed with at least one basic excipient in a ratio of 1 mole of active substance to at least 2 gram-equivalents of said basic excipient and optionally also comprising one or more further pharmaceutical excipients, said active substance and basic excipient being provided with a gastric juice-resistant lacquer coating capable of releasing said active substance in a pH range of between 5.5 and 6.8. Such a solid pharmaceutical preparation produces high and long-lasting blood and tissue levels of the active substance.

513268

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