Solid phase lipoglycopeptide library, compositions and methods

Details Solid phase lipoglycopeptide library, compositions and methods Solid phase lipoglycopeptide library, compositions and methods

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) C07H 15/00 (2006.01) C07K 1/04 (2006.01) C07K 17/00 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2249323

The present invention relates to a library of distinct substances and compositions having the general formula R-P-S-L and P-S-L, representing solid support-bound lipoglycopeptides and free lipoglycopeptides, respectively. Combinatorial methods for the preparation of various libraries are described, as well as an assay for determining the biological activity of selected members thereof. In a specific embodiment, inhibitors of bacterial peptidoglycan synthesis are described.

L'invention a pour objet une bibliothèque de substances et de compositions distinctes, de formules générales R-P-S-L et P-S-L, représentant respectivement des lipoglycopeptides liés par un support solide et des lipoglycopeptides libres. L'invention se rapporte également à des procédés combinatoires de préparation de différentes bibliothèques et à un test servant à déterminer l'activité biologique de membres sélectionnés dans cette bibliothèque. Un mode de réalisation spécifique concerne des inhibiteurs de la synthèse de peptidoglycane bactérien.

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