C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2264154
The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.
La présente invention concerne un système de support pour une synthèse en phase solide d'oligomères, par exemple, d'oligonucléotides, dans laquelle le composé de départ est lié au support via une liaison de disiloxyle. En outre, l'invention concerne un procédé pour la synthèse des oligonucléotides sur un support solide. Le système de support comprend une liaison de disiloxyle stable fournissant des chargements élevés de nucléosides sur le support. Ce procédé assure une synthèse d'oligomères pratique et aisée.
Kwiatkowski Marek
Landegren Ulf
Nilsson Mats
Fetherstonhaugh & Co.
Kwiatkowski Marek
Landegren Ulf
Nilsson Mats
Quiatech Ab
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