Solid preparation

Details Solid preparation Solid preparation

C - Chemistry, Metallurgy

07

D

C07D 209/16 (2006.01) A61K 31/404 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2391646

The present invention provides a solid preparation comprising a crystal of [3- [(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7- yloxy]acetic acid (Compound A), especially a crystal of Compound A having a particle size of not larger than 100 µm at the cumulative weight distribution value of 50 %, and not larger than 200 µm at the cumulative weight distribution value of 95 %, preferably a solid preparation having the excellent stability and the content uniformity of Compound A, which is prepared by preparing granules of the crystal of Compound A with fillers, disintegrants and binders, and then followed by mixing said granules with external excipients.

La présente invention concerne une préparation solide contenant un cristal d'acide acétique [3-[(2R)-[[(2R)-(3-chlorophényl)-2-hydroxyéthyl]amino]propyl]-1H-indol-7-yloxy] (Composé A), particulièrement un cristal de composé A dont la taille de particule est de 100 mu m maximum à la valeur cumulative de répartition du poids de 50 %, et de 200 mu m maximum à la valeur cumulative de répartition du poids de 95 %, de préférence une préparation solide caractérisé par l'excellente stabilité et l'uniformité de teneur du composé A, obtenue en préparant d'abord les granules de cristal du composé A avec des charges, des désintégrant et des liants, puis en mélangeant lesdits granules avec des excipients externes.

Affiliated with

Also associated with

Rating

Solid preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Solid preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1359971