Solid preparation and its production

Details Solid preparation and its production Solid preparation and its production

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2122286

ABSTRACT (A) A clad powdery or granular preparation of a medicinally active ingredient and (B) a powdery or granular ion exchanger such as a cation exchange resin are blended to prepare a solid preparation. The active ingredient includes .beta.-lactam antibiotics having a basic group. The clad powdery or granular preparation in- cludes not only coated preparation wherein the active ingredient or preparation is coated but also a variety of preparations in which the contact of the active ingredient with the ion exchanger is suppressed or inhibited. Polymers such as a water-soluble polymer, an enteric polymer and so on can be used as the coating agent for the coated preparation. The using amount of the ion exchanger is about 10 to 5,000 parts by weight per 100 parts by weight of the active ingredient. Said solid preparation can remarkably decrease the unpleas- ant taste and odor of the active ingredient such as bitterness, being excellent in dissolution property and absorbability of the active ingredient.

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