Solid preparations

Details Solid preparations Solid preparations

A - Human Necessities

61

K

A61K 47/38 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/30 (2006.01) A61K 9/36 (2006.01) A61K 9/48 (2006.01) A61K 31/4365 (2006.01) A61K 31/519 (2006.01) A61K 47/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2423329

It is intended to provide granules containing a large amount of a physiologically active substance which is hardly soluble in water and highly water-repellent, and solid preparations containing these granules which are excellent in the disintegration properties and the elution of the physiologically active substance. Namely, (1) granules containing a physiologically active substance and a cellulose-based disintegrating agent; (2) granules containing a physiologically active substance, a cellulose-based disintegrating agent and a binder; (3) solid preparations comprising granules (1) or (2) as described above, a cellulose-based disintegrating agent and a stearic acid-based lubricant; and (4) the solid preparations (3) as described above which are shaped into ellipsoidal tablets.

L'invention concerne, d'une part, des granulés contenant une grande quantité d'une substance physiologiquement active difficilement soluble dans l'eau et hautement hydrophobe et, d'autre part, des préparations solides contenant ces granulés présentant d'excellentes propriétés de délitement et d'élution de la substance physiologiquement active. L'invention concerne (1) des granulés contenant une substances physiologiquement active et un agent de délitement à base de cellulose; (2) des granulés contenant une substance physiologiquement active, un agent de délitement à base de cellulose et un liant; (3) des préparations solides comprenant les granulés (1) ou (2) susmentionnés, un agent de délitement et un lubrifiant à base d'acide stéarique; et (4) les préparations solides (3) susmentionnées taillées en forme de comprimés ellipsoïdaux.

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