Solid solution of an antifungal agent with enhanced...

Details Solid solution of an antifungal agent with enhanced... Solid solution of an antifungal agent with enhanced...

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/496 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2258679

A pharmaceutical composition in the form of a substantially amorphous solid solution comprising an antifungal compound of formula (I), wherein X is F; and R1 is formula (1) or an ester or ether of said compound of formula (I); and a soluble or insoluble polymer such as: povidone or crospovidone, wherein the ratio of said compound to said polymer is about 1:3 to about 1:6 is disclosed.

Composition pharmaceutique se présentant sous la forme d'une solution solide sensiblement amorphe comprenant un composé antifongique ayant la formule (I) dans laquelle X représente F et R1 représente la formule (1) ou un ester ou éther dudit composé de la formule (I); et un polymère soluble ou insoluble tel que le povidone ou le crospovidone. Le rapport entre ledit composé et ledit polymère étant de 1:3 environ à 1:6 environ.

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