Solid state forms of racemic ilaprazole

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2674347

The invention relates to crystalline forms of racemic ilaprazole, 2[[(4-methoxy-3-methyl-2-pyridinyl)-methyl]sulfinyl]-5-(1H-pyrrol-1-yl) 1H-Benzimidazole. The invention also relates to a pharmaceutical composition for inhibiting gastric acid secretion comprising a crystalline Form of ilaprazole according to the invention in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier. The invention also provides methods of treatment for various acid-related gastrointestinal (GI) disorders.

L'invention se rapporte à des formes cristallines de l'ilaprazole racémique, le 2[[(4-méthoxy-3-méthyl-2-pyridinyl)-méthyl]sulfinyl]-5-(1H-pyrrol-1-yl) 1H-Benzimidazole. L'invention se rapporte également à une composition pharmaceutique pour inhiber la sécrétion d'acide gastrique comprenant une forme cristalline de l'ilaprazole selon l'invention en une quantité efficace pour inhiber la sécrétion d'acide gastrique et un véhicule pharmaceutiquement acceptable. L'invention concerne également des procédés de traitement pour divers troubles gastrointestinaux liés aux acides (GI).

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