Solid tumor treatment method and composition

Details Solid tumor treatment method and composition Solid tumor treatment method and composition

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2067178

A liposome composition for delivering a compound to a solid tumor via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid deriva- tized with hydrophilic polymer, and have sizes in a selected size range between 0.07 and 0.12 microns. After intravenous adminis- tration, the liposomes are taken up by the tumor within 24-48 hours, for site-specific release of entrapped compound into the tu- mor. In one composition for use in treating a solid tumor, the compound is an anthracycline antibiotic drug which is entrapped in the liposomes at a concentration of greater than about 50 µg agent/µMole liposome lipid.

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