A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
128/104
A61K 9/22 (2006.01) A61K 9/00 (2006.01)
Patent
CA 1320886
9876S/5385A IX136Y TITLE OF THE INVENTION A SOLUBILITY MODULATED DRUG DELIVERY DEVICE ABSTRACT OF THE DISCLOSURE The instant invention is directed to a drug-delivery device for the controlled release of a therapeutically active ingredient into an environment of use which comprises: (A) a core composition comprising (a) a solubility modulating agent which is either (i) surrounded by a water insoluble coat containing at least one pore forming additive dispersed throughout said coat, or (ii) dispersed in a matrix substrate, and 9876S/5385A - i - IX136Y (b) a diffusible water soluble therapeutically active ingredient; and (B) a water insoluble wall surrounding said core composition and prepared from (i) a polymer material that is permeable to water but substantially impermeable to solute and (ii) 0.1 to 75% by weight, based on the total weight of (i) and (ii), of at least one water leachable pore forming additive dispersed throughout said wall; or (C) a substantially imperforate water insoluble wall surrounding said core composition and prepared from a semipermeable material substantially impermeable to core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a means for release of the therapeutic agent through the water insoluble wall.
578060
Mcclelland Gregory A.
Zentner Gaylen M.
Goudreau Gage Dubuc
Merck & Co. Inc.
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