Solubility optimization of immunobinders

Details Solubility optimization of immunobinders Solubility optimization of immunobinders

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2728829

The invention provides methods of using sequence based analysis and rational strategies to improve the solubility of immunobinders, and in particular of single chain antibodies (scFvs). The invention provides methods of engineering immunobinders, and in particular scFvs, by performing one or more substitutions with hydrophilic residues identified by analysis of a database of selected, stable scFv sequences. The invention also provides immunobinders with optimized solubility prepared according to the engineering methods of the invention.

L'invention concerne des méthodes d'utilisation de stratégies rationnelles et d'analyse fondées sur des séquences pour améliorer la solubilité d'agents de liaison immunologique, et en particulier d'anticorps monocaténaires (scFv). L'invention concerne des méthodes d'ingénierie d'agents de liaison immunologique, et en particulier des scFv, par réalisation d'une ou plusieurs substitutions avec des résidus hydrophiles identifiés par analyse d'une base de données de séquences scFv stables sélectionnées. L'invention concerne également des agents de liaison immunologique à solubilité optimisée préparés selon les méthodes d'ingénierie de l'invention.

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