Solubility parameter based drug delivery system and method...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) A61F 13/02 (2006.01) A61L 15/26 (2006.01) A61L 15/58 (2006.01)

Patent

CA 2110914

The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug. an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution. followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.

Le procédé d'ajustement de concentration de saturation d'un médicament dans une composition transdermique appliquée sur la peau consiste à mélanger des polymères ayant des paramètres de solubilité différents de manière à moduler l'administration de médicaments. Ce procédé permet d'obtenir un taux prédéterminé de perméation du médicament dans et à travers la peau. Dans un mode de réalisation, une composition dermique de la présente invention comprend un médicament, un polymère d'acrylate et un polysiloxane. Les compositions dermiques peuvent être produites par plusieurs méthodes connues de préparation de composition adhésive contenant un médicament, y compris le mélange des polymères, du médicament et d'ingrédients additionnels en solution, ce mélange étant suivi de l'élimination des solvants utilisés dans le processus. Le procédé et la composition de cette invention permettent le chargement d'une quantité arbitrairement choisie de médicaments dans la formulation dermique et l'ajustement de la vitesse d'administration du médicament contenu dans la composition à travers la peau, tout en conservant des caractéristiques acceptables de cisaillement, adhésion et de décollement.

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