Solubilization of protein aggregates

Details Solubilization of protein aggregates Solubilization of protein aggregates

C - Chemistry, Metallurgy

07

K

150/9, 530/3.18

C07K 14/08 (2006.01) C07K 1/113 (2006.01) C07K 14/445 (2006.01) C07K 14/61 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1281849

SOLUBILIZATION OF PROTEIN AGGREGATES ABSTRACT OF THE DISCLOSURE A method for the recovery of proteins includes providing a source of protein in an insoluble form and a source of at least one cationic surfactant, the insoluble protein is treated with the at least one cationic surfactant in an amount sufficient to effect solubilization without substantial modification to the structural backbone of the protein. A polar organic solvent may be used in combination with the cationic surfactant. Suitable surfactants include cetyl trimethylammonium cations, cetyl pyridinium cations, tetradecyl trimethylammonium cations, dodecyl trimethylammonium cations, mixed n-alkyl dimethyl benzyl ammonium cations, N,N-dimethyl-N-[2-[-[4-(1,1,3,3,-tetramethyl butyl) phenoxy]ethyoxy]ethyl]benzenemethanaminium cations.

524987

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