Solubilization of proteins for pharmaceutical compositions...

Details Solubilization of proteins for pharmaceutical compositions... Solubilization of proteins for pharmaceutical compositions...

C - Chemistry, Metallurgy

07

K

530/17.08, 167/1

C07K 17/08 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1305051

Abstract of the Disclosure A pharmaceutical composition is prepared wherein a biologically active conjugated protein is dissolved in an aqueous carrier medium in the absence of a solubilizing agent. The unconjugated protein, which is not readily water-soluble at pH 6-8 without such solubilizing agent, is covalently conjugated to polyproline via a flexible spacer arm and exhibits substantial biological activity.

551549

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