Solubilized platinum(ii) complexes

Details Solubilized platinum(ii) complexes Solubilized platinum(ii) complexes

C - Chemistry, Metallurgy

07

F

167/119, 260/429

C07F 15/00 (2006.01) A61K 31/55 (2006.01) A61K 31/555 (2006.01)

Patent

CA 1263867

ABSTRACT This invention relates to a platinum-amine com- pound of the general formula: cis-[Pt(A)2(X)2]; wherein A represents a polyhydroxylated amine or A2 represents a poly- hydroxylated diamine, and X represents anionic ligands selected from halo and carboxylato or X2 represents dicarboxylato, sulfato, orthophosphato or pyrophosphato, or a combination of aquo and sulfato, orthophosphato, or pyrophosphato. These compounds exhibit anti-tumor properties, whilst being highly water soluble, and combine high activity with low mammalian toxicity.

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