Solubilized topoisomerase poisons

Details Solubilized topoisomerase poisons Solubilized topoisomerase poisons

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/4375 (2006.01) A61K 31/5025 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01)

Patent

CA 2467774

The invention provides compounds of formula (I) wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.

L'invention concerne des composés de formule générale (I) dans laquelle A, B, W, Y, Z, et R¿1 ?ont la signification indiquée dans la description, ainsi que leurs sels pharmaceutiquement acceptables. L'invention concerne également des compositions pharmaceutiques comprenant un composé de formule générale (I), des procédés de préparation desdits composés de formule générale (I), des produits intermédiaires utiles dans la préparation desdits composés de formule générale (I), et des méthodes thérapeutiques de traitement du cancer faisant intervenir lesdits composés de formule générale (I).

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