C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/20 (2006.01) A61K 31/10 (2006.01) A61K 31/22 (2006.01) A61K 31/222 (2006.01) A61K 31/225 (2006.01) A61P 3/06 (2006.01)
Patent
CA 2134679
The invention provides a class of water-soluble probucol derivatives having one or more ester groups replacing the phenyl hydroxyl groups of the probucol molecule. Some derivatives have polar or charged functionalities such as carboxylic acid groups, amino groups, aldehyde groups and amide groups located on the ester groups. Some of these compounds are spontaneously hy- drolyzable in typical biological milieus. The present invention also provides method of treating an animal with probucol by ad- ministering a water-soluble probucol prodrug to the animal.
Atherogenics Inc.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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