Soluble beta amyloid precursor protein secretion promoters

A - Human Necessities – 61 – K

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A61K 45/00 (2006.01) A61K 31/4706 (2006.01) A61K 31/4709 (2006.01) A61K 31/498 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01) C07D 215/233 (2006.01) C07D 215/38 (2006.01) C07D 215/42 (2006.01) C07D 215/44 (2006.01) C07D 241/42 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2405163

Compounds represented by the following general formula (I), salts thereof or prodrugs thereof, use of the same, and a process for producing the same wherein R1 and R2 represent each hydrogen, lower alkyl, etc.; the ring A represents an optionally substituted benzene ring; X represents oxygen, etc.; and Y represents CH or N. Because of having a potent effect of promoting the secretion of soluble beta amyloid precursor proteins, these compounds and the like inhibit functional disorders and apoptosis of cells (in particular, nerve cells) mediated by the thus secreted soluble beta amyloid precursor proteins having a neurotrophic factor-like effect.

L'invention concerne des composés représentés par la formule générale suivante (I), des sels ou des promédicaments de ceux-ci, l'utilisation et un procédé de préparation associés, R?1¿ et R?2¿ représentant chaque hydrogène, alkyle inférieur, etc; l'anneau A représentant un anneau de benzène substitué de manière optionnelle; X représentant l'oxygène, etc. et Y représentant CH ou N. Ces composés et analogue inhibent des troubles fonctionnels et l'apopotose cellulaire (en particulier des cellules nerveuses) médiés par le précurseur de la protéine bêta-amyloïde ainsi sécrétée ayant un effet du type facteur neurotrophique, en raison de leur puissant effet de promotion de la sécrétion du précurseur soluble de la protéine bêta-amyloïde.

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