Soluble epoxide hydrolase inhibitors

Details Soluble epoxide hydrolase inhibitors Soluble epoxide hydrolase inhibitors

A - Human Necessities

61

K

A61K 31/18 (2006.01) A61P 9/12 (2006.01) C07C 311/47 (2006.01) C07C 311/50 (2006.01) C07D 295/12 (2006.01) C07D 295/22 (2006.01)

Patent

CA 2664365

Disclosed are sulfonamide compounds of formula (I), wherein R1-R3, Y and m are as defined in the claims, and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH-mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetes-related diseases.

L'invention décrit des composés et des compositions de sulfonamide inhibant l'époxyde hydrolase soluble (sEH), des procédés pour préparer les composés et les compositions ainsi que des procédés pour traiter des patients avec de tels composés et de telles compositions. Les composés, les compositions et les procédés sont utiles pour traiter une diversité de maladies régulées par sEH, dont l'hypertension, les maladies cardiovasculaires, inflammatoires, pulmonaires et les maladies associées au diabète.

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