Soluble epoxide hydrolase inhibitors

Details Soluble epoxide hydrolase inhibitors Soluble epoxide hydrolase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 295/192 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) C07C 275/42 (2006.01) C07D 211/58 (2006.01) C07D 211/62 (2006.01)

Patent

CA 2657120

Disclosed are urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, and diabetes-related diseases.

L'invention concerne des composés urée et thiourée et des compositions pour inhiber l'époxyde hydrolase soluble (sEH), des procédés de préparation des composés et compositions, et des procédés de traitement de patients avec de tels composés et compositions. Les composés, compositions et procédés sont utiles pour traiter une série de maladies à médiation sEH, y compris l'hypertension, les maladies cardiovasculaires, inflammatoires et associées au diabète.

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