C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61P 9/12 (2006.01) C07D 211/96 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2666482
Disclosed are urea compounds, stereoisomer, or pharmaceutical acceptable salt thereof, and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related. diseases. Formula (I) wherein: X is C=O or SO2; Y is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalky!. aryl. substituted aryl, heteroaryl, and substituted heteroaryl; Z is independently selected from the group consisting of halogen and haloalkyl; n is an integer equal to 1, 2, or 3; and p is an integer equal to 1, 2, or 3,
L'invention concerne des composés d'urée, des stéréo-isomères, ou leur sel acceptable du point de vue pharmaceutique, et des compositions qui inhibent l'époxyde hydrolase soluble (sEH), des procédés pour préparer les composés et les compositions, et des procédés pour traiter des patients à l'aide de tels composés et de telles compositions. Les composés, compositions et procédés sont utiles pour traiter diverses maladies facilitées par le sEH, y compris des maladies d'hypertension, cardiovasculaires, inflammatoires, pulmonaires et liées au diabète.
Aavula Bhaskar R.
Anandan Sampath Kumar
Gless Richard D. Jr.
Arete Therapeutics Inc.
Torys Llp
LandOfFree
Soluble epoxide hydrolase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Soluble epoxide hydrolase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Soluble epoxide hydrolase inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2046952