Soluble fragments of the sars-cov spike glycoprotein

Details Soluble fragments of the sars-cov spike glycoprotein Soluble fragments of the sars-cov spike glycoprotein

C - Chemistry, Metallurgy

07

K

C07K 14/165 (2006.01) A61K 38/16 (2006.01) A61K 39/215 (2006.01) A61K 39/42 (2006.01)

Patent

CA 2533113

The invention relates generally to the spike protein from the virus (SARS-CoV) that is etiologically linked to severe acute respiratory syndrome (SARS); polypeptides and peptide fragments of the spike protein, and conservative variants thereof; nucleic acid segments and constructs that encode the spike protein, polypeptides and peptide fragments of the spike protein, and conservative variants thereof, and coupled proteins that include the spike protein or a portion thereof; peptidomimetics; vaccines; methods for vaccination and treatment of severe acute respiratory syndrome; antibodies; aptamers; and kits containing antibodies or aptamers that bind to the spike protein.

L'invention décrit de façon générale la protéine de spicule du virus (SRAS-CoV) qui est un facteur étiologique du syndrome respiratoire aigu sévère (SRAS); des fragments de polypeptides et de peptides de la protéine de spicule, ainsi que des variants conservateurs de ceux-ci; des segments d'acides nucléiques et des produits de recombinaison qui codent la protéine de spicule, des fragments de polypeptides et de peptides de la protéine de spicule, ainsi que des variants conservateurs de ceux-ci, des protéines couplées qui contiennent tout ou partie de la protéine de spicule; des peptidomimétiques; des vaccins; des procédés de vaccination et de traitement du syndrome respiratoire aigu sévère; des anticorps ; des aptamères; ainsi que des kits contenant les anticorps ou les aptamères qui se lient à la protéine de spicule.

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