C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/715 (2006.01) A61K 38/17 (2006.01) C12N 15/12 (2006.01) C12N 15/19 (2006.01) G01N 33/566 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2633213
A polypeptide-dimer built of two identical monomeric fragments comprising the domains 1 to 3 of the extracellular (soluble) part of glycoprotein (gp) 130 and a certain polypeptide spacer are described, which are covalently linked with each other and which bear significant advantages concerning their production rate in host cells, their improved purification and their potential to bind to IL-6/soluble IL-6 receptor complexes. Furthermore, a pharmaceutical composition containing said dimeric molecule and various medical uses are described.
La présente invention a pour objet une construction dimère de polypeptide composée de deux fragments monomères identiques comprenant les domaines 1 à 3 de la partie extracellulaire (soluble) de la glycoprotéine (gp) 130 ainsi qu'un certain espaceur polypeptidique, liés de façon covalente l'un à l'autre et conférant des avantages significatifs pour ce qui est de leur vitesse de production dans les cellules hôtes, l'amélioration de leur purification et leur potentiel à se lier aux complexes récepteurs IL-6/IL-6 soluble. En outre, une préparation pharmaceutique contenant ladite molécule dimère et diverses applications thérapeutiques sont décrites.
Seegert Dirk
Waetzig Georg H.
Conaris Research Institute Ag
Smart & Biggar
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